| NAME | POSITION TITLE |
| Jacob Brink | Research Associate |
| INSTITUTE AND LOCATION | DEGREE | YEAR | FIELD OF STUDY |
| Rijksuniversiteit Groningen, the Netherlands | B.Sc. | 1979 | Chemistry |
| Rijksuniversiteit Groningen, the Netherlands | M.Sc. | 1983 | Chemistry and Physics |
| Rijksuniversiteit Groningen, the Netherlands | Ph.D. | 1988 | Chemistry and Physics |
| Baylor College of Medicine | post-doc | 1989 - present |
|
| YEAR | RESEARCH, PROFESSIONAL EXPERIENCE AND HONORS |
| 1988 - 1990 | Research Associate, Baylor College of Medicine |
| 1990 - present | Postdoctoral Fellow, W.M. Keck Center for Computational Biology |
Roossien, F.F., Brink, J. and Robillard, G.T. (1983) A simple procedure for the synthesis of [32P]phospho-enol-pyruvate via the pyruvate kinase exchange reaction at equilibrium, Biochim. Biophys. Acta 760:185-187.
Brink, J., Hovmöller, S., Ragan, C.I., Cleeter, M.W.J., Boekema, E.J. and Van Bruggen, E.F.J. (1987) The structure of NADH:ubiquinone oxidoreductase from beef-heart mitochondria. Crystals containing an octameric arrangement of iron-sulphur protein fragments, Eur. J. Biochem. 166:287-294.
Brink, J., Boekema, E.J. and Van Bruggen, E.F.J. (1988) Electron microscopy and image analysis of the complexes I and V of the mitochondrial respiratory chain, Electron Microsc. Rev. 1:175-199.
Brink, J., Van Breemen, J.F.L., Keegstra, W. and Van Bruggen, E.F.J. (1989) Computer image analysis of two-dimensional crystals of beef heart NADH:ubiquinone oxidoreductase fragments. I. Comparison of crystal structures in various negative stains, Ultramicroscopy 27:79-90 and Ultramicroscopy 27:334.
Brink, J., Booy, F.P and Van Bruggen, E.F.J. (1989) Computer image analysis of two-dimensional crystals of beef heart NADH:ubiquinone oxidoreductase fragments. II. Comparison of frozen hydrated and negatively stained specimens, Ultramicroscopy 27:91-100.
Brink, J. and Chiu, W. (1991) Contrast analysis of cryo-images of n-paraffin recorded at 400 kV out to 2.1 Å resolution. J. Microscopy 161:279-295.
Rez, P., Chiu, W., Weiss, J.K. and Brink, J. (1991) The thickness determination of organic crystals under low dose conditions using electron energy loss spectroscopy. Microsc. Res. Tech. 21:166-170.
Brink, J., Chiu, W. and Dougherty, M. (1992) Computer-controlled spot-scan imaging of crotoxin complex crystals with 400 keV electrons at near-atomic resolution. Ultramicroscopy 46:229-240.
Leapman, R.D., Brink, J. and Chiu, W. (1993) Low-dose thickness measurement of glucose-embedded crystals crystals by electron energy loss spectroscopy and STEM dark-field imaging. Ultramicroscopy 52:157-166.
Brink, J. and Chiu, W. (1994) Applications of a Slow-Scan CCD Camera in Protein Electron Crystallography. J. Struct. Biology 113:23-34.
Brink, J. and Tam, M.W. (1996) Processing of electron diffraction patterns acquired on a slow-scan CCD camera. J. Struct. Biology 116:144-150.
Sherman, M.B., Brink, J. and Chiu, W. (1996) Performance of a slow-scan CCD camera for macromolecular imaging in a 400 kV electron cryomicroscope. Micron. 27(2):129-139.
Brink, J., Sherman, M. B., Berriman, J. and Chiu, W. (1998) Evaluation of Charging on Macromolecules in Electron Cryomicroscopy. Ultramicroscopy. 72:41-52.
Brink, J., Gross, H., Tittmann, P., Sherman, M. B. and Chiu, W. (1998) Reduction of Charging in Protein Electron Microscopy J. Microscopy. 191(1):67-73.
Frey, W., Brink, J., Schief, Jr., W.R., Chiu, W. and Vogel, V. (1998) Electron crystallographic Analysis of Two-dimensional Streptavidin Crystals coordinated to Metal-Chelated Lipid Monolayers. Biophys. J.. 74(5):2674-2679.
Brink, J., Ludtke, S., Yang, C.-Y., Gu, Z.-W., Wakil, S.J. and Chiu, W. (2002) Quaternary structure of human fatty acid synthase by electron cryomicroscopy. Proc. Nat'l. Acad. Sci. 99(1):138-143.
Ming, D., Kong, Y., Wakil, S.J. Brink, J. and Ma, J. (2002) Domain movements in human fatty acid synthase by quantized elastic deformational model. Proc. Nat'l. Acad. Sci. Accepted for publication.