Zhixian Zhang, Ph.D 
Department of Biochemistry
National Center for Macromolecular Imaging
Baylor College of Medicine
One Baylor Plaza, Houston, TX, 77030, U.S.A.
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- Tel: (713) 798-6996
- zzhang@blake.3dem.bioch.bcm.tmc.edu
- curriculum vitae (cv in NIH
format)
Research
Interests
Cryo-Electron Microscopy
Imaging and 3-D Reconstruction of Transduction Complexes"
Two
Structures of Membrane-Protein Complexes that Mediate Signal
Transduction
in
Vertebrate Photoreceptors Have Been
Studied:
(1)
Electron Crystallography and helical reconstruction
of
"Helical arrays
of the photoreceptor G protein transducin, Gt, bound
to
tubular lipid bilayers ( "Gt
Tubes")"
(2) Single
Particle Analysis of randomly
oriented photoreceptor cGMP
phosphodiesterase PDE6.
Signal Transduction Complexes
G
protein-coupled receptors are the largest class
of receptors in humans, and in eukaryotic organisms in
general
(Bourne, 1997). Pathways involving G proteins are the
targets of most drugs used for therapeutic
purposes, as well
as for most of those used legally or illegally for
non-therapeutic reasons.
Electron Crystallography
and helical reconstruction of " Helical
arrays
of the photoreceptor G protein transducin, Gt, bound
to tubular lipid bilayers ( "Gt Tubes")", JBC
, June 1, 2004. "How a G protein
binds a membrane"
- Projects
had been studied:
» 
Cryo-Electron
Microscopy
Imaging and
3-D Reconstruction of Double Starnd DNA Bacterophage P22
in Dr.
Wah Chiu's lab of
National Center for Macromolecular Imaging
»Electron Crystallography of Organic Small
Molecules with Non-linear Optical Properties
In Dr. I.G.Voigt-Martin's
group of Mainz University in Germany
(26K)
Publications:
- Structural
Dependence of Non-linear Optical Properties of
4-Dimethylamino-3-Cyanobiphenly,
(I.G.Voigt-Martin, Z.X. Zhang,D.H.Yan, Wortmann, Colloid and Polymer
Science
275,18-37(1997).
- The Use of Maximum Entropy Statistics
Combined with
Simulation Methods
to Determine the Structure of 4-Dimethylamino-3-Cyanobiphenly,
(I.G.Voigt-Martin,
Z.X. Zhang, U.Kolb, C.Gilmore, Ultramicroscopy 68,43-59 (1997).
- Studies on the structural character of
Nitrophenylhexylurethane
crystal with high S.H.G. effect using electron diffraction simulation
of
molecular modelling method (I.G.Voigt-Mrtin, Z.X. Zhang, Wortmann,
accepted
by Acta Cryst. A)
- The Use of Electron Crystallography to
Determine the
Structural
Dependence of Non-linear Optical Propertis in Organic Molecules"
Z.X.Zhang,
C.Gilmore, U.kolb, I.G.Voigt-Martin, Collected in (International Union
of Crystallography XV II Congress and General Assembly) Seattle,
Washington,
USA August 8-17,1996, pageC-393).
Cryo-Electron
Microscopy
Imaging and
3-D Reconstruction of Double Starnd DNA Bacterophage P22