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Education
B.S. Applied Physics, St. Mary's University (1993)
Ph.D. Structural and Computational Biology and Molecular Biophysics (1998)
Post-doc, The Scripps Research Institute (1998-2005)

Carlos Cantu III, Ph.D.
Department: Scientist, Vaccine Technology
Address: Neurome, Inc.
11149 North Torrey Pines Rd.
La Jolla, CA 92037

Phone: 858-677-0466
Fax: 858-677-0458
Email: texcar@sbcglobal.net
Web:
Honors

Research Topic

Engineering Substrate Specificity Changes in Tem-1 Beta-Lactamase With Limited Amino Acid Substitutions
Research Description
Selected Publications

  • Callaway, C., Wang, J.-P., Slavik, K., Needleman, D., Seryshev, A., Cantu, C. III, Wu, Y., Jayaraman, T., Marks, A., and Hamilton, S.L. (1994). Localization of the High and Low Affinity [3H]-Ryanodine Binding Sites on the Skeletal Muscle Ca2+ Release Channel. J. Biol. Chem. 269: 15876-15884.
  • Cantu, C. III, Huang, W., and Palzkill, T. (1996). Selection and Characterization of Amino Acid Substitutions at Residues 237-240 of TEM-1 Beta-lactamase with Altered Substrate Specificity for Aztreonam and Ceftazidime. J. Biol. Chem. 271: 22538-22545.
  • Cantu, C. III, Huang, W., and Palzkill, T. (1997). Cephalosporin Substrate Specificity Determinants of TEM-1 Beta-lactamase. J. Biol. Chemi. 272: 29144-29150.
  • Cantu, C. III, and Palzkill, T. (1998). The role of residue 238 of Beta-lactamase in the hydrolysis of extended-spectrum Beta-lactam antibiotics. J. Biol. Chem. 273: 26603-26609.
  • Petrosino, J., Cantu, C. III, and Palzkill, T. (1998). Beta-lactamases: Protein evolution in real time. Trends Microbiol. 6: 323-327.
  • Cantu, C. III, Benlagha, K., Savage, P.B., Bendelac, A. and Teyton, L. (2003). The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs. J. Immunol. 170(9): 4673-4682.
  • Zhou, D.*, Cantu, C. III*, Sagiv, Y., Schrantz, N., Kulkarni, A.B., Qi, X., Mahuran, D.J., Morales, C.R., Grabowski, G.A., Benlagha, K., Savage, P., Bendelac, A. and Teyton, L. (2004). Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science. 303(5657): 523-527. *co-first author
  • Goff, R.D., Gao, Y., Mattner, J., Zhou, D., Yin, N., Cantu, C. III, Teyton, L., Bendelac, A. and Savage, P.B. (2004). Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. J. Am. Chem. Soc. 126(42): 13602-13603.
  • Zhou, D., Mattner, J., Cantu, C. III, Schrantz, N., Yin, N., Gao, Y., Sagiv, Y., Hudspeth, K., Wu, Y.P., Yamashita, T., Teneberg, S., Wang, D., Proia, R.L., Levery, S.B., Savage, P.B., Teyton, L. and Bendelac, A. (2004). Lysosomal glycosphingolipid recognition by NKT cells. Science 306(5702): 1786-1789.
  • Mattner, J., Debord, K.L., Ismail, N., Goff, R.D., Cantu, C. III, Zhou, D., Saint-Mezard, P., Wang, V., Gao, Y., Yin, N., Hoebe, K., Schneewind, O., Walker, D., Beutler, B., Teyton, L., Savage, P.B. and Bendelac, A. (2005). Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434(7032): 525-529.
  • Zajonc, D.M., Cantu, C. III, Mattner, J., Zhou, D., Savage, P.B., Bendelac, A., Wilson, I.A., Teyton, L. (2005). Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol. 2005 Aug;6(8):810-8.

Last edited on: April 26, 2006


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