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Education
B.S. Neurobiology, University of Texas at Dallas (2001)
Ph.D. Structural & Computational Biology and Molecular Biophysics, Baylor College of Medicine (2007)
Postdoctoral Fellow, Department of Molecular and Human Genetics, Baylor College of Medicine (2008)
David Mittelman
David Mittelman, Ph.D.
Baylor College of Medicine
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Email: david.mittelman@rice.edu
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Honors

1997 - Research Grant Recipient, RISE Foundation
1998 - Academic Excellence Scholarship Recipient, University of Texas at Dallas
2003 - NEI T32 Training Grant Recipient
Research Topic

Evolvability
Research Description
I am interested in the genetic and epigenetic pathways that promote genome variation and the role of these processes in adaptive evolution. For a list of most recent publications, search David Mittelman at PubMed.
Selected Publications

  • D. Mittelman, C. Moye, J. Morton, K. Sykoudis, Y. Lin, D. Carroll, J.H. Wilson (2008) Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells, submitted.
  • D.H. Morgan, D.M. Kristensen, D. Mittelman, O. Lichtarge (2006) ET Viewer: An Application for Predicting and Visualizing Functional Sites in Protein Structures. Bioinformatics, 22(16):2049-50.
  • V. Gorbunova, A. Seluanov, D. Mittelman, and J.H. Wilson (2004) Demethylation of the genome strongly destabilizes CAG/CTG trinucleotide repeats in mammalian cells. Hum. Mol. Genet., 13(23):2979-2989.
  • A. Seluanov, D. Mittelman, O.M. Pereira-Smith, J.H. Wilson, and V. Gorbunova (2004) DNA end joining becomes less efficient and more error-prone during cellular senescence. Proc. Natl. Acad. Sci. USA, 101(20):7624-9.
  • D. Mittelman, R. Sadreyev, and N. Grishin (2003) Probabilistic scoring measures for profile-profile comparison yield more accurate short seed alignments. Bioinformatics, 19(12):1531-1539.
  • R.P. Balog, Y. Ponce de Souza, H. Tang, G. DeMasellis, B. Gao, A. Avila, D. Gaban, D. Mittelman, J.D. Minna, K.J. Luebke, and H.R. Garner (2002) Parallel assessment of CpG methylation by two-color hybridization with oligonucleotide arrays. Analytical Biochemistry, 309(2):301-310.
  • K.J. Luebke, R.P. Balog, D. Mittelman and H.R. Garner (2002) Digital Optical Chemistry: A Novel System for the Rapid Fabrication of Custom Oligonucleotide Arrays, a chapter in Microfabricated Sensors, Application of Optical Technology for DNA Analysis, Usmani and Wai Tak Law, editors, American Chemical Society Publications.
  • A. Kulkarni, N. Williams, Y. Lian, J.D. Wren, D. Mittelman, A. Pertsemlidis, and H.R. Garner (2002) ARROGANT: an application to manipulate large gene collections. Bioinformatics, 18(11):1410-1417.
  • J.D. Wren, D. Mittelman, and H.R. Garner (2002) SIGNAL - Sequence Information and Genomic Analysis. Computer Methods and Programs in Biomedicine, 68(2):177-181.
  • A. Pertsemlidis, B. Miller, A. Pande, D. Mittelman, P. Schilling, M. Wei, M. Lerman, J. Minna, and H. Garner (2000) PANORAMA - An Integrated Web-Based Sequence Analysis Tool and Its Role in Gene Discovery. Genomics, 70(3): 300-306.

Last edited on: June 24, 2008


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