Automated Software Package
for
Icosahedral Virus Reconstruction

Jeffrey A. Lawton

Program in Cell and Molecular Biology, Baylor College of Medicine Houston, TX 77030

And

B. V. Venkataram Prasad

Verna and Marrs McLean Department of Biochemistry and W.M. Keck Center for Computational Biology, Baylor College of Medicine,
Houston, TX 77030


The three-dimensional reconstruction of icosahedral viruses from electron micrograph images has become an important tool for understanding virus structure, function, and pathogenesis. We have developed an integrated suite of software to automate most of the operations involved in producing these reconstructions from EM images. Our package combines the analytical capabilities of pre-existing algorithms together with approaches we have developed to produce an interactive working environment which enhances the efficiency and usefulness of this approach to the structural analysis of icosahedral viruses.

Copyright 1996 Academic Press, Inc.

Full paper.


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