Publications by Year



2017 publications


  • Bridging the Gap Between Safety and Immunogenicity: A Chikungunya Fever Vaccine Utilizing an Insect-Specific Virus Platform. (2017) Erasmus, J, Auguste, A, Kaelber, J, Luo, H, Rossi, S, Fenton, K, Leal, G, Kim, D, Chiu, W, Wang, T, Frolov, I, Nasar, F, & Weaver, S Nat Med 23(2):192-199. PMCIDPMC5296253
  • Visualizing Adsorption of Cyanophage P-SSP7 onto Marine Prochlorococcus. (2017) Murata, K, Zhang, Q, Gerardo Galaz-Montoya, J, Fu, C, Coleman, ML, Osburne, MS, Schmid, MF, Sullivan, MB, Chisholm, SW, & Chiu, W Sci Rep 7:44176. PMCID
  • SuRVoS: Super-Region Volume Segmentation workbench. (2017) Luengo, I, Darrow, MC, Spink, MC, Sun, Y, Dai, W, He, CY, Chiu, W, Pridmore, T, Ashton, AW, Duke, EM, Basham, M, & French, AP J Struct Biol 10.1016/j.jsb.2017.02.007. PMID: 28246039
  • Accurate model annotation of a near-atomic resolution cryo-EM map. (2017) Hryc, CF, Chen, DH, Afonine, PV, Jakana, J, Wang, Z, Haase-Pettingell, C, Jiang, W, Adams, PD, King, JA, Schmid, MF, & Chiu, W Proc Natl Acad Sci U S A 114:3103-3108. PMID: 28270620
  • An allosteric transport mechanism for the AcrAB-1 TolC Multidrug Efflux Pump. (2017) Wang, Z, Fan, G, Hryc, CF, Blaza, JN, Serysheva, II, Schmid, MF, Chiu, W, Luisi, BF, & Du, D ELife. PMCID



  • 2016 publications


  • Fabrication of RNA 3D Nanoprisms for Loading and Protection of Small RNAs and Model Drugs. (2016) Emil F. Khisamutdinov, Daniel L. Jasinski, Hui Li, Kaiming Zhang, Wah Chiu, Peixuan Guo Advanced Materials DOI: 10.1002/adma.201603180
  • Asymmetric cryo-EM structure of the canonical Allolevivirus Qbeta reveals a single maturation protein and the genomic ssRNA in situ. (2016) Gorzelnik, KV, Cui, Z, Reed, CA, Jakana, J, Young, R, & Zhang, J Proc Natl Acad Sci U S A 113(41):11519-11524. PMID27671640
  • Bridging the Gap Between Safety and Immunogenicity: A Chikungunya Fever Vaccine Utilizing an Insect-Specific Virus Platform. (2016) Erasmus, J, Auguste, A, Kaelber, J, Luo, H, Rossi, S, Fenton, K, Leal, G, Kim, D, Chiu, W, Wang, T, Frolov, I, Nasar, F, & Weaver, S Nature Medicine.:accepted. PMID:
  • Structural and Molecular Bases of Rod Photoreceptor Morphogenesis and Disease. (2016) Wensel, TG, Zhang, Z, Anastassov, IA, Gilliam, JC, He, F, Schmid, MF, & Robichaux, MA Prog. Retin. Eye Res. in press. PMID27352937
  • Single-Particle Refinement and Variability Analysis in EMAN2.1. (2016) Ludtke, SJ Methods Enzymol 579:159-189. PMID27572727
  • High resolution single particle refinement in EMAN2.1. (2016) Bell, JM, Chen, M, Baldwin, PR, & Ludtke, SJ Methods 100:25-34. PMIDPMC4848122
  • De Novo Modeling in Cryo-EM Density Maps with Pathwalking. (2016) Chen, M, Baldwin, PR, Sludtke, SL, & Baker, ML J Struct Biol:in press. PMID27436409
  • Tandem CAR T cells targeting HER2 and IL13Ralpha2 mitigate tumor antigen escape. (2016) Hegde, M, Mukherjee, M, Grada, Z, Pignata, A, Landi, D, Navai, SA, Wakefield, A, Fousek, K, Bielamowicz, K, Chow, KK, Brawley, VS, Byrd, TT, Krebs, S, Gottschalk, S, Wels, WS, Baker, ML, Dotti, G, Mamonkin, M, Brenner, MK, Orange, JS, & Ahmed, N J Clin Invest 126(8):3036-3052. PMCIDPMC4966331.
  • Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions. (2016) Roh, SH, Kasembeli, MM, Galaz-Montoya, JG, Chiu, W, & Tweardy, DJ Biophys J 110(11):2377-2385. PMCIDPMC4906440.
  • TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. (2016) Zhao, X, Chen, XQ, Han, E, Hu, Y, Paik, P, Ding, Z, Overman, J, Lau, AL, Shahmoradian, SH, Chiu, W, Thompson, LM, Wu, C, & Mobley, WC Proc Natl Acad Sci U S A 113(38):E5655-5664. PMCID
  • Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomography. (2016) Darrow, MC, Zhang, Y, Cinquin, BP, Smith, EA, Boudreau, R, Rochat, RH, Schmid, MF, Xia, Y, Larabell, CA, & Chiu, W J Cell Sci 129(18):3511-3517. PMCID
  • Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting. (2016) Li, H, Zhang, K, Pi, F, Guo, S, Shlyakhtenko, L, Chiu, W, Shu, D, & Guo, P Adv Mater 28(34):7501-7507. PMCID
  • Resolution and Probabilistic Models of Components in CryoEM Maps of Mature P22 Bacteriophage. (2016) Grigore Pintilie, Dong-Hua Chen, Cameron A. Haase-Pettingell, Jonathan A. King, Wah Chiu Biophysical Journal. Volume 110, Issue 4, 23 February 2016, Pages 827 - 839. PMCID in progress.
  • The Electron Microscopy eXchange (EMX) initiative. (2016) Marabini R, Ludtke SJ, Murray SC, Chiu W, de la Rosa-Trevin JM, Patwardhan A, Heymann JB, & Carazo JM Journal of structural biology 194(2):156-163. PMCID in progress.
  • Quantifying Variability of Manual Annotation in Cryo-Electron Tomograms. (2016) Hecksel CW, Darrow MC, Dai W, Galaz-Montoya JG, Chin JA, Mitchell PG, Chen S, Jakana J, Schmid MF, & Chiu W Microsc Microanal 10.1017/S1431927616000799:1-10. PMCID in progress.
  • Designer nanoscale DNA assemblies programmed from the top down. (2016) Veneziano R, Ratanalert S, Zhang K, Zhang F, Yan H, Chiu W, & Bathe M Science 10.1126/ science.aaf4388. PMCID in progress.
  • Tools for model building and optimization into near atomic resolution electron cryo-microscopy density maps. (2016) Dimaio F & Chiu W Methods in enzymology In press. PMCID in progress.
  • EMDataBank unified data resource for 3DEM. (2016) Lawson CL, Patwardhan A, Baker ML, Hryc C, Garcia ES, Hudson BP, Lagerstedt I, Ludtke SJ, Pintilie G, Sala R, Westbrook JD, Berman HM, Kleywegt GJ, & Chiu W Nucleic acids research 44(D1):D396-403. PMCID4702818
  • Alignment algorithms and per-particle CTF correction for single particle cryo-electron tomography. (2016) Galaz-Montoya,JG, Hecksel,CW, Baldwin,PR, Wang,E, Weaver,SC, Schmid,MF, Ludtke,SJ, & Chiu W Journal of structural biology 194(3):383-394. PMCID4846534.
  • Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO. (2016) Roh SH, Kasembeli M, Galaz-Montoya JG, Trnka M, Lau WC, Burlingame A, Chiu W, & Tweardy DJ The Journal of biological chemistry 291(9):4732-4741. PMCID4813495.



  • 2015 publications


  • Structural diversity of supercoiled DNA. (2015) Irobalieva, RN, Fogg, JM, Catanese, DJ, Sutthibutpong, T, Chen, M, Barker, AK, Ludtke, SJ, Harris, SA, Schmid, MF, Chiu, W, & Zechiedrich, L Nature communications 6:8440. PMCID4608029
  • Erratum: Structural diversity of supercoiled DNA. (2015) Irobalieva, RN, Fogg, JM, Catanese, DJ, Sutthibutpong, T, Chen, M, Barker, AK, Ludtke, SJ, Harris, SA, Schmid, MF, Chiu, W, & Zechiedrich, L Nature communications 6:8440. PMID: 26511109
  • Outcome of the First wwPDB Hybrid/Integrative Methods Task Force Workshop. (2015) Sali, A, Berman, HM, Schwede, T, Trewhella, J, Kleywegt, G, Burley, SK, Markley, J, Nakamura, H, Adams, P, Bonvin, AM, Chiu, W, Peraro, MD, Di Maio, F, Ferrin, TE, Grunewald, K, Gutmanas, A, Henderson, R, Hummer, G, Iwasaki, K, Johnson, G, Lawson, CL, Meiler, J, Marti-Renom, MA, Montelione, GT, Nilges, M, Nussinov, R, Patwardhan, A, Rappsilber, J, Read, RJ, Saibil, H, Schroder, GF, Schwieters, CD, Seidel, CA, Svergun, D, Topf, M, Ulrich, EL, Velankar, S, & Westbrook, JD Structure 23(7):1156-1167.
  • Gating machinery of InsP3R channels revealed by electron cryomicroscopy. (2015) Fan, G, Baker, ML, Wang, Z, Baker, MR, Sinyagovskiy, PA, Chiu, W, Ludtke, SJ, & Serysheva, II Nature 527(7578):336-341.
  • Bolaamphiphiles as carriers for siRNA delivery: From chemical syntheses to practical applications. (2015) Gupta K, Afonin KA, Viard M, Herrero V, Kasprzak W, Kagiampakis I, Kim T, Koyfman AY, Puri A, Stepler M, Sappe A, KewalRamani VN, Grinberg S, Linder C, Heldman E, Blumenthal R, Shapiro BA J Control Release. 2015 Jul 4;213:142-151. doi: 10.1016/j.jconrel.2015.06.041.
  • Dimeric Organization of Blood Coagulation Factor VIII bound to Lipid Nanotubes. (2015) Dalm D, Galaz-Montoya JG, Miller JL, Grushin K, Villalobos A, Koyfman AY, Schmid MF, Stoilova-McPhie S. Sci Rep. 2015 Jun 17;5:11212. doi: 10.1038/srep11212.
  • Domain organization and conformational plasticity of the G protein effector, PDE6. (2015) Zhang Z, He F, Constantine R, Baker ML, Baehr W, Schmid MF, Wensel TG, Agosto MA. J Biol Chem. Jul 10;290(28):17131-2. doi: 10.1074/jbc.A115.647636.
  • Erratum: Domain organization and conformational plasticity of the G protein effector, PDE6. (2015) Zhang Z, He F, Constantine R, Baker ML, Baehr W, Schmid MF, Wensel TG, Agosto MA. J Biol Chem. May 15;290(20):12833-43. doi: 10.1074/jbc.M115.647636.
  • Single particle tomography in EMAN2. (2015) Galaz-Montoya JG, Flanagan J, Schmid MF, Ludtke SJ. J Struct Biol. 2015 Jun;190(3):279-90. doi: 10.1016/j.jsb.2015.04.016. Epub 2015 May 5
  • Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin. (2015) Tan, Z, Dai, W, van Erp, TG, Overman, J, Demuro, A, Digman, MA, Hatami, A, Albay, R, Sontag, EM, Potkin, KT, Ling, S, Macciardi, F, Bunney, WE, Long, JD, Paulsen, JS, Ringman, JM, Parker, I, Glabe, C, Thompson, LM, Chiu, W, & Potkin, SG Molecular psychiatry 10.1038/mp.2015.81. PMCID in progress
  • Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography. (2015) Darrow, MC, Sergeeva, OA, Isas, JM, Galaz-Montoya, JG, King, JA, Langen, R, Schmid, MF, & Chiu, W The Journal of biological chemistry 290(28):17451-17461. PMCID4498080.
  • CTF Challenge: Result summary (2015) Marabini, R, Carragher, B, Chen, S, Chen, J, Cheng, A, Downing, KH, Frank, J, Grassucci, RA, Bernard Heymann, J, Jiang, W, Jonic, S, Liao, HY, Ludtke, SJ, Patwari, S, Piotrowski, AL, Quintana, A, Sorzano, CO, Stahlberg, H, Vargas, J, Voss, NR, Chiu, W, & Carazo, JM Journal of structural biology 10.1016/j.jsb.2015.04.003.
  • An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions. (2015) Leung, DW, Borek, D, Luthra, P, Binning, JM, Anantpadma, M, Liu, G, Harvey, IB, Su, Z, Endlich-Frazier, A, Pan, J, Shabman, RS, Chiu, W, Davey, RA, Otwinowski, Z, Basler, CF, & Amarasinghe, GK Cell reports 11(3):376-389.
  • Structure of a biologically active estrogen receptor-coactivator complex on DNA. (2015) Yi, P, Wang, Z, Feng, Q, Pintilie, GD, Foulds, CE, Lanz, RB, Ludtke, SJ, Schmid, MF, Chiu, W, & O'Malley, BW Molecular cell 57(6):1047-1058.
  • A newly isolated reovirus has the simplest genomic and structural organization of any reovirus.(2015) Auguste, AJ, Kaelber, JT, Fokam, EB, Guzman, H, Carrington, CV, Erasmus, JH, Kamgang, B, Popov, VL, Jakana, J, Liu, X, Wood, TG, Widen, SG, Vasilakis, N, Tesh, RB, Chiu, W, & Weaver, SC .,Journal of virology 89(1):676-687.
  • Lemon-shaped halo archaeal virus His1 with uniform tail but variable capsid structure. (2015) Hong, C, Pietila, MK, Fu, CJ, Schmid, MF, Bamford, DH, & Chiu, W., Proceedings of the National Academy of Sciences of the United States of America 112(8):2449-2454.



  • 2014 publications


  • Structural similarities in DNA packaging and delivery apparatuses in Herpesvirus and dsDNA bacteriophages. (2014) Rixon FJ, Schmid MF. Curr Opin Virol. 2014 Apr;5:105-10. doi: 10.1016/j.coviro.2014.02.003. Epub 2014 Apr 17. Review.
  • A 3D cellular context for the macromolecular world.(2014) Patwardhan, A, Ashton, A, Brandt, R, Butcher, S, Carzaniga, R, Chiu, W, Collinson, L, Doux, P, Duke, E, Ellisman, MH, Franken, E, Grunewald, K, Heriche, JK, Koster, A, Kuhlbrandt, W, Lagerstedt, I, Larabell, C, Lawson, CL, Saibil, HR, Sanz-Garcia, E, Subramaniam, S, Verkade, P, Swedlow, JR, & Kleywegt, GJ Nature structural & molecular biology 21(10):841-845.
  • A structural model of the genome packaging process in a membrane-containing double stranded DNA virus.(2014) Hong, C, Oksanen, HM, Liu, X, Jakana, J, Bamford, DH, & Chiu, W PLoS biology 12(12):e1002024.
  • Oligomeric State of Purified Transient Receptor Potential Melastatin-1 (TRPM1), a Protein Essential for Dim Light Vision. (2014) Agosto MA, Zhang Z, He F, Anastassov IA, Wright SJ, McGehee J, Wensel TG., J Biol Chem.
  • Capsid expansion mechanism of bacteriophage T7 revealed by multistate atomic models derived from cryo-EM reconstructions. (2014) Guo F, Liu Z, Fang PA, Zhang Q, Wright ET, Wu W, Zhang C, Vago F, Ren Y, Jakana J, Chiu W, Serwer P, Jiang W., Proc Natl Acad Sci U S A.
  • Identifying the assembly pathway of cyanophage inside the marine bacterium using electron cryo-tomography. (2014) Dai, W., Schmid, M.F., King, J.A. and Chiu, W., Microbial Cell
  • Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography. (2014) Shahmoradian, SH, Galiano, MR, Wu, C, Chen, S, Rasband, MN, Mobley, WC, Chiu, W., J. Vis. Exp.
  • Structure of the AcrAB-TolC multidrug efflux pump. (2014) Du, D, Wang, Z, James, NR, Voss, JE, Klimont, E, Ohene-Agyei, T, Venter, H, Chiu, W, & Luisi, BF, Nature
  • Modulation of STAT3 folding and function by TRiC/CCT chaperonin. (2014) Kasembeli, M, Lau, WC, Roh, SH, Eckols, TK, Frydman, J, Chiu, W, & Tweardy, DJ, PLoS Biology
  • Chaperonin-containing TCP-1 complex directly binds to the cytoplasmic domain of the LOX-1 receptor. (2014) Bakthavatsalam, D, Soung, RH, Tweardy, DJ, Chiu, W, Dixon, RA, & Woodside, DG, FEBS letters
  • Editorial overview: Virus structure and function. (2014) Chiu, W, Crepin, T, & Ruigrok, RW, Current opinion in virology
  • Cryo-EM techniques to resolve the structure of HSV-1 capsid-associated components. (2014) Rochat, RH, Hecksel, CW, & Chiu, W, Methods in molecular biology
  • Multiple functional roles of the accessory I-domain of bacteriophage P22 coat protein revealed by NMR structure and CryoEM modeling. (2014) Rizzo, AA, Suhanovsky, MM, Baker, ML, Fraser, LC, Jones, LM, Rempel, DL, Gross, ML, Chiu, W, Alexandrescu, AT, & Teschke, CM , Structure
  • Protruding knob-like proteins violate local symmetries in an icosahedral marine virus. (2014) Gipson, P, Baker, ML, Raytcheva, D, Haase-Pettingell, C, Piret, J, King, JA, & Chiu, W, Nature Communications
  • An atomic model of brome mosaic virus using direct electron detection and real-space optimization. (2014) Wang, Z, Hryc, CF, Bammes, B, Afonine, PV, Jakana, J, Chen, DH, Liu, X, Baker, ML, Kao, C, Ludtke, SJ, Schmid, MF, Adams, PD, & Chiu, W, Nature Communications.
  • Crystal structure of a nematode-infecting virus. (2014) Guo, YR, Hryc, CF, Jakana, J, Jiang, H, Wang, D, Chiu, W, Zhong, W, & Tao, YJ, Proc Natl Acad Sci USA
  • Zernike phase contrast electron cryo-tomography applied to marine cyanobacteria Infected with cyanophages. (2014) Dai, W, Fu, C, Khant, HA, Ludtke, SJ, Schmid, MF and Chiu, W, Nature Protocols



  • 2013 publications


  • Reprogramming an ATP-driven protein machine into a light-gated nanocage. (2013) Hoersch D, Roh SH, Chiu W, Kortemme T, Nature Nanotechnology
  • Exploring new limits in complex biological structures. (2013) Wagner, G and Chiu, W., Current Opinion in Structural Biology
  • Visualizing virus assembly intermediates inside marine cyanobacteria. (2013) Dai W, Fu C, Raytcheva D, Flanagan J, Khant HA, Liu X, Rochat RH, Haase-Pettingell C, Piret J, Ludtke SJ, Nagayama K, Schmid MF, King JA, Chiu W, Nature
  • Single-particle cryo-EM of calcium release channels: structural validation. (2013) Ludtke SJ, Serysheva II, Curr Opin Struct Biol
  • In Silico, In Vitro, and In Vivo Studies Indicate the Potential Use of Bolaamphiphiles for Therapeutic siRNAs Delivery. (2013) Kim T, Afonin KA, Viard M, Koyfman AY, Sparks S, Heldman E, Grinberg S, Linder C, Blumenthal RP, Shapiro BA, Mol Ther Nucleic Acids
  • Visualizing GroEL/ES in the act of encapsulating a folding protein. (2013) Chen DH, Madan D, Weaver J, Lin Z, Schröder GF, Chiu W, Rye HS, Cell
  • Validation of cryo-EM structure of IP₃R1 channel. (2013) Murray SC, Flanagan J, Popova OB, Chiu W, Ludtke SJ, Serysheva II, Structure
  • Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers. (2013) Sergeeva OA, Chen B, Haase-Pettingell C, Ludtke SJ, Chiu W, King JA, J Biol Chem
  • Cryo-EM model validation using independent map reconstructions. (2013) DiMaio F, Zhang J, Chiu W, Baker D, Protein Sci
  • Validated near-atomic resolution structure of bacteriophage epsilon15 derived from cryo-EM and modeling. (2013) Baker ML, Hryc CF, Zhang Q, Wu W, Jakana J, Haase-Pettingell C, Afonine PV, Adams PD, King JA, Jiang W, Chiu W, Proc Natl Acad Sci U S A
  • EMEN2: an object oriented database and electronic lab notebook. (2013) Rees I, Langley E, Chiu W, Ludtke SJ, Microsc Microanal
  • Cryo-EM structure of a molluscan hemocyanin suggests its allosteric mechanism. (2013) Zhang Q, Dai X, Cong Y, Zhang J, Chen DH, Dougherty MT, Wang J, Ludtke SJ, Schmid MF, Chiu W, Structure
  • TRiC's tricks inhibit huntingtin aggregation. (2013) Shahmoradian SH, Galaz-Montoya JG, Schmid MF, Cong Y, Ma B, Spiess C, Frydman J, Ludtke SJ, Chiu W, Elife



  • 2012 publications


  • Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration. (2012) Gilliam, JC, Chang, JT, Sandoval, IM, Zhang, Y, Li, T, Pittler, SJ, Chiu, W, Wensel, TG, Cell
  • Comparison of Segger and other methods for segmentation and rigid-body docking of molecular components in cryo-EM density maps. (2012) Pintilie G, Chiu W, Biopolymers
  • Gorgon and pathwalking: macromolecular modeling tools for subnanometer resolution density maps. (2012) Baker ML, Baker MR, Hryc CF, Ju T, Chiu W, Biopolymers
  • The 2010 cryo-EM modeling challenge. (2012) Ludtke SJ, Lawson CL, Kleywegt GJ, Berman H, Chiu W, Biopolymers
  • Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration. (2012) Gilliam JC, Chang JT, Sandoval IM, Zhang Y, Li T, Pittler SJ, Chiu W, Wensel TG, Cell
  • The molecular architecture of the eukaryotic chaperonin TRiC/CCT. (2012) Leitner A, Joachimiak LA, Bracher A, Mönkemeyer L, Walzthoeni T, Chen B, Pechmann S, Holmes S, Cong Y, Ma B, Ludtke S, Chiu W, Hartl FU, Aebersold R, Frydman J, Structure
  • Constructing and validating initial Cα models from subnanometer resolution density maps with pathwalking. (2012) Baker MR, Rees I, Ludtke SJ, Chiu W, Baker ML, Structure
  • Supramolecular non-amyloid intermediates in the early stages of α-synuclein aggregation. (2012) Fauerbach JA, Yushchenko DA, Shahmoradian SH, Chiu W, Jovin TM, Jares-Erijman EA, Biophys J
  • Direct electron detection yields cryo-EM reconstructions at resolutions beyond 3/4 Nyquist frequency. (2012) Bammes BE, Rochat RH, Jakana J, Chen DH, Chiu W, J Struct Biol
  • An examination of the electrostatic interactions between the N-terminal tail of the Brome Mosaic Virus coat protein and encapsidated RNAs. (2012) Ni P, Wang Z, Ma X, Das NC, Sokol P, Chiu W, Dragnea B, Hagan M, Kao CC, J Mol Biol
  • Filamentous, mixed micelles of triblock copolymers enhance tumor localization of indocyanine green in a murine xenograft model. (2012) Kim TH, Mount CW, Dulken BW, Ramos J, Fu CJ, Khant HA, Chiu W, Gombotz WR, Pun SH, Mol Pharm
  • Outcome of the first electron microscopy validation task force meeting. (2012) Henderson R, Sali A, Baker ML, Carragher B, Devkota B, Downing KH, Egelman EH, Feng Z, Frank J, Grigorieff N, Jiang W, Ludtke SJ, Medalia O, Penczek PA, Rosenthal PB, Rossmann MG, Schmid MF, Schröder GF, Steven AC, Stokes DL, Westbrook JD, Wriggers W, Yang H, Young J, Berman HM, Chiu W, Kleywegt GJ, Lawson CL, Structure
  • Paraneoplastic thrombocytosis in ovarian cancer. (2012) Stone RL, Nick AM, McNeish IA, Balkwill F, Han HD, Bottsford-Miller J, Rupairmoole R, Armaiz-Pena GN, Pecot CV, Coward J, Deavers MT, Vasquez HG, Urbauer D, Landen CN, Hu W, Gershenson H, Matsuo K, Shahzad MM, King ER, Tekedereli I, Ozpolat B, Ahn EH, Bond VK, Wang R, Drew AF, Gushiken F, Lamkin D, Collins K, DeGeest K, Lutgendorf SK, Chiu W, Lopez-Berestein G, Afshar-Kharghan V, Sood AK, N Engl J Med
  • Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle. (2012) Cong Y, Schröder GF, Meyer AS, Jakana J, Ma B, Dougherty MT, Schmid MF, Reissmann S, Levitt M, Ludtke SL, Frydman J, Chiu W, EMBO J
  • A tail-like assembly at the portal vertex in intact herpes simplex type-1 virions. (2012) Schmid MF, Hecksel CW, Rochat RH, Bhella D, Chiu W, Rixon FJ, PLoS Pathog
  • Identification of ATP-binding regions in the RyR1 Ca²⁺ release channel. (2012) Popova OB, Baker MR, Tran TP, Le T, Serysheva II, PLoS One
  • Principles of virus structural organization. (2012) Prasad BV, Schmid MF, Adv Exp Med Biol



  • 2011 publications


  • Crystal structure of the cytoplasmic N-terminal domain of subunit I, a homolog of subunit a, of V-ATPase. (2011) Srinivasan S, Vyas NK, Baker ML, Quiocho FA, J Mol Biol
  • The structure of barmah forest virus as revealed by cryo-electron microscopy at a 6-angstrom resolution has detailed transmembrane protein architecture and interactions. (2011) Kostyuchenko VA, Jakana J, Liu X, Haddow AD, Aung M, Weaver SC, Chiu W, Lok SM, J Virol
  • Practical performance evaluation of a 10k × 10k CCD for electron cryo-microscopy. (2011) Bammes BE, Rochat RH, Jakana J, Chiu W, J Struct Biol
  • Effect of the peptide secondary structure on the peptide amphiphile supramolecular structure and interactions. (2011) Missirlis D, Chworos A, Fu CJ, Khant HA, Krogstad DV, Tirrell M, Langmuir
  • Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure. (2011) Zhang J, Ma B, DiMaio F, Douglas NR, Joachimiak LA, Baker D, Frydman J, Levitt M, Chiu W, Structure
  • Modeling protein structure at near atomic resolutions with Gorgon. (2011) Baker ML, Abeysinghe SS, Schuh S, Coleman RA, Abrams A, Marsh MP, Hryc CF, Ruths T, Chiu W, Ju T, J Struct Biol
  • Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. (2011) Moon JJ, Suh H, Bershteyn A, Stephan MT, Liu H, Huang B, Sohail M, Luo S, Um SH, Khant H, Goodwin JT, Ramos J, Chiu W, Irvine DJ, Nat Mater
  • Structure of Trypanosoma brucei flagellum accounts for its bihelical motion. (2011) Koyfman AY, Schmid MF, Gheiratmand L, Fu CJ, Khant HA, Huang D, He CY, Chiu W, Proc Natl Acad Sci U S A
  • Structural basis for scaffolding-mediated assembly and maturation of a dsDNA virus. (2011) Chen DH, Baker ML, Hryc CF, DiMaio F, Jakana J, Wu W, Dougherty M, Haase-Pettingell C, Schmid MF, Jiang W, Baker D, King JA, Chiu W, Proc Natl Acad Sci U S A
  • Dual action of ATP hydrolysis couples lid closure to substrate release into the group II chaperonin chamber. (2011) Douglas NR, Reissmann S, Zhang J, Chen B, Jakana J, Kumar R, Chiu W, Frydman J, Cell
  • EMDataBank.org: unified data resource for CryoEM. (2011) Lawson CL, Baker ML, Best C, Bi C, Dougherty M, Feng P, van Ginkel G, Devkota B, Lagerstedt I, Ludtke SJ, Newman RH, Oldfield TJ, Rees I, Sahni G, Sala R, Velankar S, Warren J, Westbrook JD, Henrick K, Kleywegt GJ, Berman HM, Chiu W, Nucleic Acids Res
  • The group II chaperonin Mm-Cpn binds and refolds human γD crystallin. (2011) Knee KM, Goulet DR, Zhang J, Chen B, Chiu W, King JA, Protein Sci
  • Electron cryomicroscopy structure of a membrane-anchored mitochondrial AAA protease. (2011) Lee S, Augustin S, Tatsuta T, Gerdes F, Langer T, Tsai FT, J Biol Chem
  • Seeing the portal in herpes simplex virus type 1 B capsids. (2011) Rochat RH, Liu X, Murata K, Nagayama K, Rixon FJ, Chiu W, J Virol
  • 4.4 Å cryo-EM structure of an enveloped alphavirus Venezuelan equine encephalitis virus. (2011) Zhang R, Hryc CF, Cong Y, Liu X, Jakana J, Gorchakov R, Baker ML, Weaver SC, Chiu W, EMBO J
  • Flexible architecture of IP3R1 by Cryo-EM. (2011) Ludtke SJ, Tran TP, Ngo QT, Moiseenkova-Bell VY, Chiu W, Serysheva II, Structure
  • Near-atomic-resolution cryo-EM for molecular virology. (2011) Hryc CF, Chen DH, Chiu W, Curr Opin Virol
  • Partially polymerized liposomes: stable against leakage yet capable of instantaneous release for remote controlled drug delivery. (2011) Qin G, Li Z, Xia R, Li F, O'Neill BE, Goodwin JT, Khant HA, Chiu W, Li KC, Nanotechnology
  • Functional and structural studies of TRP channels heterologously expressed in budding yeast. (2011) Moiseenkova-Bell V, Wensel TG, Adv Exp Med Biol
  • Single-particle electron cryotomography (cryoET). (2011) Schmid MF, Adv Protein Chem Struct Biol



  • 2010 publications


  • Cryo-EM of macromolecular assemblies at near-atomic resolution. (2010) Baker ML, Zhang J, Ludtke SJ, Chiu W, Nat Protoc
  • Workshop on molecular animation. (2010) Bromberg S, Chiu W, Ferrin TE, Structure
  • Visualizing the structural changes of bacteriophage Epsilon15 and its Salmonella host during infection. (2010) Chang JT, Schmid MF, Haase-Pettingell C, Weigele PR, King JA, Chiu W, J Mol Biol
  • CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation. (2010) Lee S, Sielaff B, Lee J, Tsai FT, Proc Natl Acad Sci U S A
  • Tracing conformational changes in proteins. (2010) Haspel N, Moll M, Baker ML, Chiu W, Kavraki LE, BMC Struct Biol
  • Electron microscopy, immunostaining, cytoskeleton visualization, in situ hybridization, and three-dimensional reconstruction of Xenopus oocytes. (2010) Bilinski SM, Jaglarz MK, Dougherty MT, Kloc M, Methods
  • 4.0-Å resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement. (2010) Cong Y, Baker ML, Jakana J, Woolford D, Miller EJ, Reissmann S, Kumar RN, Redding-Johanson AM, Batth TS, Mukhopadhyay A, Ludtke SJ, Frydman J, Chiu W, Proc Natl Acad Sci U S A
  • Radiation damage effects at four specimen temperatures from 4 to 100 K. (2010) Bammes BE, Jakana J, Schmid MF, Chiu W, J Struct Biol
  • MOTIF-EM: an automated computational tool for identifying conserved regions in CryoEM structures. (2010) Saha M, Levitt M, Chiu W, Bioinformatics
  • Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions. (2010) Pintilie GD, Zhang J, Goddard TD, Chiu W, Gossard DC, J Struct Biol
  • Structural changes in a marine podovirus associated with release of its genome into Prochlorococcus. (2010) Liu X, Zhang Q, Murata K, Baker ML, Sullivan MB, Fu C, Dougherty MT, Schmid MF, Osburne MS, Chisholm SW, Chiu W, Nat Struct Mol Biol
  • Mechanism of folding chamber closure in a group II chaperonin. (2010) Zhang J, Baker ML, Schröder GF, Douglas NR, Reissmann S, Jakana J, Dougherty M, Fu CJ, Levitt M, Ludtke SJ, Frydman J, Chiu W, Nature
  • Model of human low-density lipoprotein and bound receptor based on cryoEM. (2010) Ren G, Rudenko G, Ludtke SJ, Deisenhofer J, Chiu W, Pownall HJ, Proc Natl Acad Sci U S A
  • Automated pipeline for atlas-based annotation of gene expression patterns: application to postnatal day 7 mouse brain. (2010) Carson J, Ju T, Bello M, Thaller C, Warren J, Kakadiaris IA, Chiu W, Eichele G, Methods
  • Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography. (2010) Miyazaki Y, Irobalieva RN, Tolbert BS, Smalls-Mantey A, Iyalla K, Loeliger K, D'Souza V, Khant H, Schmid MF, Garcia EL, Telesnitsky A, Chiu W, Summers MF, J Mol Biol
  • Zernike phase contrast cryo-electron microscopy and tomography for structure determination at nanometer and subnanometer resolutions. (2010) Murata K, Liu X, Danev R, Jakana J, Schmid MF, King J, Nagayama K, Chiu W, Structure
  • Automated specimen search in cryo-TEM observation with DIFF-defocus imaging. (2010) Nakamura N, Shimizu Y, Shinkawa T, Nakata M, Bammes B, Zhang J, Chiu W, J Electron Microsc (Tokyo)
  • Rotavirus cell entry. (2010) Baker M, Prasad BV, Curr Top Microbiol Immunol
  • Semi-isometric registration of line features for flexible fitting of protein structures. (2010) Abeysinghe S, Baker ML, Chiu W, Ju T, Comput Graph Forum
  • Analyses of subnanometer resolution cryo-EM density maps. (2010) Baker ML, Baker MR, Hryc CF, Dimaio F, Methods Enzymol



  • 2009 publications


  • Refinement of protein structures into low-resolution density maps using rosetta. (2009) DiMaio F, Tyka MD, Baker ML, Chiu W, Baker D, J Mol Biol
  • Structural mechanism of SDS-induced enzyme activity of scorpion hemocyanin revealed by electron cryomicroscopy. (2009) Cong Y, Zhang Q, Woolford D, Schweikardt T, Khant H, Dougherty M, Ludtke SJ, Chiu W, Decker H, Structure
  • Interprotofilament interactions between Alzheimer's Abeta1-42 peptides in amyloid fibrils revealed by cryoEM. (2009) Zhang R, Hu X, Khant H, Ludtke SJ, Chiu W, Schmid MF, Frieden C, Lee JM, Proc Natl Acad Sci U S A
  • Estimating contrast transfer function and associated parameters by constrained non-linear optimization. (2009) Yang C, Jiang W, Chen DH, Adiga U, Ng EG, Chiu W, J Microsc
  • Hot on the trail of TRP channel structure. (2009) Moiseenkova-Bell VY, Wensel TG, J Gen Physiol
  • Characterization of antibiotic peptide pores using cryo-EM and comparison to neutron scattering. (2009) Han M, Mei Y, Khant H, Ludtke SJ, Biophys J
  • JADAS: a customizable automated data acquisition system and its application to ice-embedded single particles. (2009) Zhang J, Nakamura N, Shimizu Y, Liang N, Liu X, Jakana J, Marsh MP, Booth CR, Shinkawa T, Nakata M, Chiu W, J Struct Biol
  • Disruption of human plasma high-density lipoproteins by streptococcal serum opacity factor requires labile apolipoprotein A-I. (2009) Han M, Gillard BK, Courtney HS, Ward K, Rosales C, Khant H, Ludtke SJ, Pownall HJ, Biochemistry
  • Ryanodine receptor structure: progress and challenges. (2009) Hamilton SL, Serysheva II, J Biol Chem
  • Rotavirus architecture at subnanometer resolution. (2009) Li Z, Baker ML, Jiang W, Estes MK, Prasad BV, J Virol
  • Identifying Components in 3D Density Maps of Protein Nanomachines by Multi-scale Segmentation. (2009) Pintilie G, Zhang J, Chiu W, Gossard D, IEEE NIH Life Sci Syst Appl Workshop



  • 2008 publications


  • Location and flexibility of the unique C-terminal tail of Aquifex aeolicus co-chaperonin protein 10 as derived by cryo-electron microscopy and biophysical techniques. (2008) Chen DH, Luke K, Zhang J, Chiu W, Wittung-Stafshede P, J Mol Biol
  • Signal transducing membrane complexes of photoreceptor outer segments. (2008) Wensel TG, Vision Res
  • Mouse early oocytes are transiently polar: three-dimensional and ultrastructural analysis. (2008) Kloc M, Jaglarz M, Dougherty M, Stewart MD, Nel-Themaat L, Bilinski S, Exp Cell Res
  • Redox-triggered contents release from liposomes. (2008) Ong W, Yang Y, Cruciano AC, McCarley RL, J Am Chem Soc
  • Structure of TRPV1 channel revealed by electron cryomicroscopy. (2008) Moiseenkova-Bell VY, Stanciu LA, Serysheva II, Tobe BJ, Wensel TG, Proc Natl Acad Sci U S A
  • Functional maturation of the human antibody response to rotavirus. (2008) Kallewaard NL, McKinney BA, Gu Y, Chen A, Prasad BV, Crowe JE Jr, J Immunol
  • Methods for aligning and for averaging 3D volumes with missing data. (2008) Schmid MF, Booth CR, J Struct Biol
  • De novo backbone trace of GroEL from single particle electron cryomicroscopy. (2008) Ludtke SJ, Baker ML, Chen DH, Song JL, Chuang DT, Chiu W, Structure
  • Remotely triggered liposome release by near-infrared light absorption via hollow gold nanoshells. (2008) Wu G, Mikhailovsky A, Khant HA, Fu C, Chiu W, Zasadzinski JA, J Am Chem Soc
  • Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. (2008) Serysheva II, Ludtke SJ, Baker ML, Cong Y, Topf M, Eramian D, Sali A, Hamilton SL, Chiu W, Proc Natl Acad Sci U S A
  • Achievable resolution from images of biological specimens acquired from a 4k x 4k CCD camera in a 300-kV electron cryomicroscope. (2008) Chen DH, Jakana J, Liu X, Schmid MF, Chiu W, J Struct Biol
  • Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT. (2008) Booth CR, Meyer AS, Cong Y, Topf M, Sali A, Ludtke SJ, Chiu W, Frydman J, Nat Struct Mol Biol
  • Crystallographic conformers of actin in a biologically active bundle of filaments. (2008) Cong Y, Topf M, Sali A, Matsudaira P, Dougherty M, Chiu W, Schmid MF, J Mol Biol
  • Cryo-electron microscopy of coagulation Factor VIII bound to lipid nanotubes. (2008) Parmenter CD, Cane MC, Zhang R, Stoilova-McPhie S, Biochem Biophys Res Commun
  • Backbone structure of the infectious epsilon15 virus capsid revealed by electron cryomicroscopy. (2008) Jiang W, Baker ML, Jakana J, Weigele PR, King J, Chiu W, Nature
  • Protein structure fitting and refinement guided by cryo-EM density. (2008) Topf M, Lasker K, Webb B, Wolfson H, Chiu W, Sali A, Structure
  • X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus. (2008) Bornholdt ZA, Prasad BV, Nature



  • 2007 publications


  • Averaging tens to hundreds of icosahedral particle images to resolve protein secondary structure elements using a Multi-Path Simulated Annealing optimization algorithm. (2007) Liu X, Jiang W, Jakana J, Chiu W, J Struct Biol
  • Biophysical methods: structure, dynamics and gorgeous images. (2007) Chiu W, Moffat K, Curr Opin Struct Biol
  • Genome sequence, structural proteins, and capsid organization of the cyanophage Syn5: a "horned" bacteriophage of marine synechococcus. (2007) Pope WH, Weigele PR, Chang J, Pedulla ML, Ford ME, Houtz JM, Jiang W, Chiu W, Hatfull GF, Hendrix RW, King J, J Mol Biol
  • Organization of cytokeratin cytoskeleton and germ plasm in the vegetal cortex of Xenopus laevis oocytes depends on coding and non-coding RNAs: three-dimensional and ultrastructural analysis. (2007) Kloc M, Bilinski S, Dougherty MT, Exp Cell Res
  • Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins. (2007) Reissmann S, Parnot C, Booth CR, Chiu W, Frydman J, Nat Struct Mol Biol
  • Computing a family of skeletons of volumetric models for shape description. (2007) Ju T, Baker ML, Chiu W, Comput Aided Des
  • Learning-based segmentation framework for tissue images containing gene expression data. (2007) Bello M, Ju T, Carson J, Warren J, Chiu W, Kakadiaris IA, IEEE Trans Med Imaging
  • Visualizing the ATPase cycle in a protein disaggregating machine: structural basis for substrate binding by ClpB. (2007) Lee S, Choi JM, Tsai FT, Mol Cell
  • SPARX, a new environment for Cryo-EM image processing. (2007) Hohn M, Tang G, Goodyear G, Baldwin PR, Huang Z, Penczek PA, Yang C, Glaeser RM, Adams PD, Ludtke SJ, J Struct Biol
  • Identification of secondary structure elements in intermediate-resolution density maps. (2007) Baker ML, Ju T, Chiu W, Structure
  • EMAN2: an extensible image processing suite for electron microscopy. (2007) Tang G, Peng L, Baldwin PR, Mann DS, Jiang W, Rees I, Ludtke SJ, J Struct Biol
  • Electron cryotomography reveals the portal in the herpesvirus capsid. (2007) Chang JT, Schmid MF, Rixon FJ, Chiu W, J Virol
  • Ribosome binding of a single copy of the SecY complex: implications for protein translocation. (2007) Ménétret JF, Schaletzky J, Clemons WM Jr, Osborne AR, SkÃ¥nland SS, Denison C, Gygi SP, Kirkpatrick DS, Park E, Ludtke SJ, Rapoport TA, Akey CW, Mol Cell
  • Modular software platform for low-dose electron microscopy and tomography. (2007) Marsh MP, Chang JT, Booth CR, Liang NL, Schmid MF, Chiu W, J Microsc
  • DNA packaging and delivery machines in tailed bacteriophages. (2007) Johnson JE, Chiu W, Curr Opin Struct Biol
  • Single-particle electron cryomicroscopy of the ion channels in the excitation-contraction coupling junction. (2007) Serysheva II, Chiu W, Ludtke SJ, Methods Cell Biol
  • Cryoelectron microscopy of icosahedral virus particles. (2007) Jiang W, Chiu W, Methods Mol Biol



  • 2006 publications


  • 3D volume reconstruction of a mouse brain from histological sections using warp filtering. (2006) Ju T, Warren J, Carson J, Bello M, Kakadiaris I, Chiu W, Thaller C, Eichele G, J Neurosci Methods
  • Ab initio modeling of the herpesvirus VP26 core domain assessed by CryoEM density. (2006) Baker ML, Jiang W, Wedemeyer WJ, Rixon FJ, Baker D, Chiu W, PLoS Comput Biol
  • An expanded conformation of single-ring GroEL-GroES complex encapsulates an 86 kDa substrate. (2006) Chen DH, Song JL, Chuang DT, Chiu W, Ludtke SJ, Structure
  • Cryoelectron microscopy structures of rotavirus NSP2-NSP5 and NSP2-RNA complexes: implications for genome replication. (2006) Jiang X, Jayaram H, Kumar M, Ludtke SJ, Estes MK, Prasad BV, J Virol
  • Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. (2006) Araç D, Chen X, Khant HA, Ubach J, Ludtke SJ, Kikkawa M, Johnson AE, Chiu W, Südhof TC, Rizo J, Nat Struct Mol Biol
  • Structural biology of cellular machines. (2006) Chiu W, Baker ML, Almo SC, Trends Cell Biol
  • Cryo-EM asymmetric reconstruction of bacteriophage P22 reveals organization of its DNA packaging and infecting machinery. (2006) Chang J, Weigele P, King J, Chiu W, Jiang W, Structure
  • Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus. (2006) Jiang W, Chang J, Jakana J, Weigele P, King J, Chiu W, Nature
  • High-resolution molecular and antigen structure of the VP8* core of a sialic acid-independent human rotavirus strain. (2006) Monnier N, Higo-Moriguchi K, Sun ZY, Prasad BV, Taniguchi K, Dormitzer PR, J Virol
  • Structure of Halothiobacillus neapolitanus carboxysomes by cryo-electron tomography. (2006) Schmid MF, Paredes AM, Khant HA, Soyer F, Aldrich HC, Chiu W, Shively JM, J Mol Biol
  • Cryoelectron microscopy of protein IX-modified adenoviruses suggests a new position for the C terminus of protein IX. (2006) Marsh MP, Campos SK, Baker ML, Chen CY, Chiu W, Barry MA, J Virol
  • Automated segmentation of molecular subunits in electron cryomicroscopy density maps. (2006) Baker ML, Yu Z, Chiu W, Bajaj C, J Struct Biol
  • Assessing the capabilities of a 4kx4k CCD camera for electron cryo-microscopy at 300kV. (2006) Booth CR, Jakana J, Chiu W, J Struct Biol
  • Outcome of a workshop on archiving structural models of biological macromolecules. (2006) Berman HM, Burley SK, Chiu W, Sali A, Adzhubei A, Bourne PE, Bryant SH, Dunbrack RL Jr, Fidelis K, Frank J, Godzik A, Henrick K, Joachimiak A, Heymann B, Jones D, Markley JL, Moult J, Montelione GT, Orengo C, Rossmann MG, Rost B, Saibil H, Schwede T, Standley DM, Westbrook JD, Structure
  • Refinement of protein structures by iterative comparative modeling and CryoEM density fitting. (2006) Topf M, Baker ML, Marti-Renom MA, Chiu W, Sali A, J Mol Biol



  • 2005 publications


  • A digital atlas to characterize the mouse brain transcriptome. (2005) Carson JP, Ju T, Lu HC, Thaller C, Xu M, Pallas SL, Crair MC, Warren J, Chiu W, Eichele G, PLoS Comput Biol
  • Electron cryomicroscopy of single particles at subnanometer resolution. (2005) Jiang W, Ludtke SJ, Curr Opin Struct Biol
  • Mutational analysis of the SARS virus Nsp15 endoribonuclease: identification of residues affecting hexamer formation. (2005) Guarino LA, Bhardwaj K, Dong W, Sun J, Holzenburg A, Kao C, J Mol Biol
  • ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane. (2005) Blau M, Mullapudi S, Becker T, Dudek J, Zimmermann R, Penczek PA, Beckmann R, Nat Struct Mol Biol
  • A structure of the human apoptosome at 12.8 Å resolution provides insights into this cell death platform. (2005) Yu X, Acehan D, Ménétret JF, Booth CR, Ludtke SJ, Riedl SJ, Shi Y, Wang X, Akey CW, Structure
  • Fast rotational matching of single-particle images. (2005) Cong Y, Jiang W, Birmanns S, Zhou ZH, Chiu W, Wriggers W, J Struct Biol
  • Electron cryomicroscopy of biological machines at subnanometer resolution. (2005) Chiu W, Baker ML, Jiang W, Dougherty M, Schmid MF, Structure
  • Structure of Ca2+ release channel at 14 A resolution. (2005) Serysheva II, Hamilton SL, Chiu W, Ludtke SJ, J Mol Biol
  • Structural characterization of components of protein assemblies by comparative modeling and electron cryo-microscopy. (2005) Topf M, Baker ML, John B, Chiu W, Sali A, J Struct Biol
  • Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation. (2005) Passmore LA, Booth CR, Vénien-Bryan C, Ludtke SJ, Fioretto C, Johnson LN, Chiu W, Barford D, Mol Cell
  • Common ancestry of herpesviruses and tailed DNA bacteriophages. (2005) Baker ML, Jiang W, Rixon FJ, Chiu W, J Virol
  • Superparamagnetic gadonanotubes are high-performance MRI contrast agents. (2005) Sitharaman B, Kissell KR, Hartman KB, Tran LA, Baikalov A, Rusakova I, Sun Y, Khant HA, Ludtke SJ, Chiu W, Laus S, Tóth E, Helm L, Merbach AE, Wilson LJ, Chem Commun (Camb)
  • The pore structure of the closed RyR1 channel. (2005) Ludtke SJ, Serysheva II, Hamilton SL, Chiu W, Structure
  • Architecture of the ribosome-channel complex derived from native membranes. (2005) Ménétret JF, Hegde RS, Heinrich SU, Chandramouli P, Ludtke SJ, Rapoport TA, Akey CW, J Mol Biol
  • Delivery of germinal granules and localized RNAs via the messenger transport organizer pathway to the vegetal cortex of Xenopus oocytes occurs through directional expansion of the mitochondrial cloud. (2005) Wilk K, Bilinski S, Dougherty MT, Kloc M, Int J Dev Biol
  • Structural biology of old world and new world alphaviruses. (2005) Paredes A, Weaver S, Watowich S, Chiu W, Arch Virol Suppl



  • 2004 publications


  • Structure of the acrosomal bundle. (2004) Schmid MF, Sherman MB, Matsudaira P, Chiu W, Nature
  • Mitochondrial ATP synthasome: three-dimensional structure by electron microscopy of the ATP synthase in complex formation with carriers for Pi and ADP/ATP. (2004) Chen C, Ko Y, Delannoy M, Ludtke SJ, Chiu W, Pedersen PL, J Biol Chem
  • Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane fusion. (2004) Paredes AM, Ferreira D, Horton M, Saad A, Tsuruta H, Johnston R, Klimstra W, Ryman K, Hernandez R, Chiu W, Brown DT, Virology
  • Seeing GroEL at 6 A resolution by single particle electron cryomicroscopy. (2004) Ludtke SJ, Chen DH, Song JL, Chuang DT, Chiu W, Structure
  • Automatic particle selection: results of a comparative study. (2004) Zhu Y, Carragher B, Glaeser RM, Fellmann D, Bajaj C, Bern M, Mouche F, de Haas F, Hall RJ, Kriegman DJ, Ludtke SJ, Mallick SP, Penczek PA, Roseman AM, Sigworth FJ, Volkmann N, Potter CS, J Struct Biol
  • Formation, architecture and polarity of female germline cyst in Xenopus. (2004) Kloc M, Bilinski S, Dougherty MT, Brey EM, Etkin LD, Dev Biol
  • Experimental verification of conformational variation of human fatty acid synthase as predicted by normal mode analysis. (2004) Brink J, Ludtke SJ, Kong Y, Wakil SJ, Ma J, Chiu W, Structure
  • How a G protein binds a membrane. (2004) Zhang Z, Melia TJ, He F, Yuan C, McGough A, Schmid MF, Wensel TG, J Biol Chem
  • Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer. (2004) Mao Y, Vyas NK, Vyas MN, Chen DH, Ludtke SJ, Chiu W, Quiocho FA, EMBO J
  • Structural rearrangements in the membrane penetration protein of a non-enveloped virus. (2004) Dormitzer PR, Nason EB, Prasad BV, Harrison SC, Nature
  • A 9 angstroms single particle reconstruction from CCD captured images on a 200 kV electron cryomicroscope. (2004) Booth CR, Jiang W, Baker ML, Zhou ZH, Ludtke SJ, Chiu W, J Struct Biol
  • Interactions between the inner and outer capsids of bluetongue virus. (2004) Nason EL, Rothagel R, Mukherjee SK, Kar AK, Forzan M, Prasad BV, Roy P, J Virol



  • 2003 publications


  • Cross-correlation and merging of crystallographic reflections derived from cryoelectron micrographs of 3D crystals: application to the Limulus acrosomal bundle. (2003) Schmid MF, J Struct Biol
  • Structure of isolated nucleocapsids from venezuelan equine encephalitis virus and implications for assembly and disassembly of enveloped virus. (2003). Paredes, A., Alwell-Warda, K., Weaver, S.C., Chiu, W., and Watowich, S.J. J Virol, 77: 659-664.
  • Structure of the herpesvirus major capsid protein. (2003). Bowman, B. R., Baker, M. L., Rixon, F. J., Chiu, W., and Quiocho, F. A. EMBO J, 22: 757-765.
  • Coat protein fold and maturation transition of bacteriophage P22 seen at sub-nanometer resolutions. (2003). Jiang, W., Li, Z., Zhang, Z., Baker, M.L., Prevelige, P.E., and Chiu, W. Nat Struct Biol, 10: 131-135.
  • Studying large viruses. (2003) Rixon, F. and Chiu, W. Adv Protein Chem, 64:413-444.
  • Determination of icosahedral virus structures by electron cryomicroscopy at subnanometer resolution. (2003). Zhou, Z.H. and Chiu, W. Adv Protein Chem, 64: 93-130.
  • Mitochondrial ATP synthasome. Cristae-enriched membranes and a multiwell detergent screening assay yield dispersed single complexes containing the ATP synthase and carriers for Pi and ADP/ATP. (2003). Ko, Y.H., Delannoy, M., Hullihen, J., Chiu, W., and Pedersen, P.L. J Biol Chem, 278: 12305-12309.
  • Structure of the type 1 Inositol 1,4,5-trisphosphate receptor revealed by electron cryomicroscopy. (2003). Serysheva, I.I, Bare, D.J., Ludtke, S.J., Kettlun, C.S., Chiu, W., and Mignery, G.A.J Biol Chem, 278: 21319-21322.
  • Architecture of the herpes simplex virus major capsid protein derived from structural bioinformatics. (2003). Baker, M. L., Jiang, W., Bowman, B. R., Zhou, Z. H., Quiocho, F. A., Rixon, F. J., and Chiu, W. J Mol Biol, 331: 447-456.
  • A geometric database for gene expression data. (2003). Ju, T., Warren, J., Eichele, G., Thaller, C., Chiu, W., and Carson, J. Symp Geom Process, pp.166-176.
  • The structure of ClpB, a molecular chaperone that rescues proteins from an aggregated state. (2003). Lee, S., Sowa, M.E., Watanabe, Y., Sigler, P.B., Chiu, W., Yoshida, M., and Tsai, F.T. Cell, 115: 229-40.
  • Electron beam coater for reduction of charging in ice-embedded biological specimens using Ti88Si12 alloy. (2003). Sherman, M. B. and Chiu, W. Microscopy and Microanalysis, 9: 566-573.
  • Object oriented database and electronic notebook for transmission electron microscopy. (2003). Ludtke, S. J., Nason, L., Tu, H., Peng, L., and Chiu, W. Microscopy and Microanalysis, 9: 556-565.
  • Focal pair merging for contrast enhancement of single particles. (2003). Ludtke, S.J. and Chiu, W. J Struct Biol, 144: 73-78.
  • Applications of a bilateral denoising filter in biological electron microscopy. (2003). Jiang, W., Baker, M.L., Wu, Q., Bajaj, A. and Chiu, W. J Struct Biol, 144: 114-122.
  • Structure of triglyceride-rich human low-density lipoproteins according to cryoelectron microscopy. (2003). Sherman, M.B., Orlova, E.V., Decker, G.L., Chiu, W., and Pownall, H.J. Biochemistry, 42: 14988-93.



  • 2002 publications


  • Quaternary structure of human fatty acid synthase by electron cryomicroscopy. (2002). Brink, J., Ludtke, S. J., Yang, C. Y., Gu, Z. W., Wakil, S. J., and Chiu, W. Proc Natl Acad Sci USA, 99: 138-143.
  • Deriving folds of macromolecular complexes through electron cryomicroscopy and bioinformatics approaches. (2002). Chiu, W., Baker, M.L., Jiang, W., and Zhou, Z.H. Curr Opin Struct Biol, 12: 263-269.
  • High resolution structural studies of complex icosahedral viruses: a brief overview. (2002). Chiu, W. and Rixon, F.J. Virus Res, 82: 9-17.
  • Electron Cryo-microscopy of VAT, the Archaeal p97/CDC48 Homologue from Thermoplasma acidophilum. (2002). Rockel, B., Jakana, J., Chiu, W., and Baumeister,W. J Mol Biol, 317: 673-681.
  • Bilamellar cationic liposomes protect adenovectors from preexisting humoral immune responses. (2002). Yotnda, P., Chen, D.H., Chiu, W., Piedra, P.A., Davis, A., Templeton, N.S., and Brenner, M.K. Mol Ther, 5: 233-241.
  • Structure of the voltage-gated L-type Ca2+ channel by electron cryomicroscopy. (2002). Serysheva, I.I., Ludtke, S. J., Baker, M. R., Chiu, W., and Hamilton, S. L. Proc Natl Acad Sci USA, 99: 10370-10375.
  • The skeletal muscle Ca2+ release channel has an oxidoreductase-like domain. (2002). Baker, M. L., Serysheva, I. I., Sencer, S., Wu, Y., Ludtke, S. J., Jiang, W., Hamilton, S. L., and Chiu, W. Proc Natl Acad Sci USA, 99: 12155-12160.



  • 2001 publications


  • A 11.5 Å single particle reconstruction of GroEL using EMAN. (2001). Ludtke, S.J., Jakana, J., Song, J.L., Chuang, D., and Chiu, W. J Mol Biol, 314: 253-262.
  • Intrinsically disordered protein.(2001) Dunker, A.K., Lawson, J.D., Brown, C.J., Romero, P., Oh, J., Oldfield, C.J., Campen, A. M., Ratliff, C.M., Hipps, K.W., Ausio, J., Nissen, M.S., Reeves, R., Kang, C., Kissinger, C.R., Bailey, R.W., Griswold, M.D., Chiu, W., Garner, E.C., and Obradovic, Z. J Mol Graph Model, 19: 1-34.
  • Bridging the information gap: Computational tools for intermediate resolution structure interpretation. (2001). Jiang, W., Baker, M. L., Ludtke, S. J., and Chiu, W. J Mol Biol, 308:1033-1044.
  • Finding and using local symmetry in identifying lower domain movements in hexon subunits of the herpes simplex virus type 1 B capsid. (2001). He, J., Schmid, M. F., Zhou, Z. H., Rixon, F., and Chiu, W. J Mol Biol, 309:903-914.
  • Fourier amplitude decay of electron cryomicroscopic images of single particles and effects on structure determination. (2001). Saad, A., Ludtke, S. J., Jakana, J., Rixon, F. J., Tsuruta, H., and Chiu, W. J Struct Biol, 133: 32-42.
  • Electron diffraction of protein crystals. (2001).Chiu, W., M. G. Rossmann and E. Arnold. In: IUCr Tables for Crystallography, Crystallography of Biological Macromolecules eds., Vol. F, Dordrecht: Kluwer Academic Publishers, The Netherlands, pp 423-427.
  • Web-based simulation for contrast transfer function and envelope functions. (2001). Jiang, W. and Chiu, W. Microsc Microanal, 7:329-334.
  • Electron micrographs: computer enhancement and use for molecular 3-dimensional reconstruction.(2001). Ludtke, S. J. and Chiu, W. In: Encyclopedia of Life Sciences, vol. 6, pp. 212-217. London: Nature Publishing Group. http://www.els.net/
  • Editorial comments on special issue on single particle analysis. (2001). Ludtke, S. J. and Chiu, W. J Struct Biol, 133: 89.
  • Electron cryomicroscopy and bioinformatics suggest protein fold models for rice dwarf virus. (2001). Zhou, Z. H., Baker, M. L., Jiang, W., Dougherty, M., Jakana, J., Dong, G., Lu, G., and Chiu, W. Nature Struct Biol, 8: 868-873.
  • Venezuelan equine encephalomyelitis virus structure and its divergence from old world alphaviruses. (2001). Paredes, A., Alwell-Warda, K., Weaver, S. C., Chiu, W., and Watowich, S. J. J Virology, 75: 9532-9537.
  • The pattern of tegument-capsid interaction in the herpes simplex virus type 1 virion is not influenced by the small hexon protein VP26. (2001). Chen, D. H., Jakana, J., McNab, D., Mitchell, J., Zhou, Z. H., Dougherty, M., Chiu, W., and Rixon, F. J. J Virology, 75: 11863-11867.
  • Semi-automated icosahedral particle reconstruction at sub-nanometer resolution. (2001). Jiang, W., Li, Z., Zhang, Z., Booth, C.R., Baker, M.L., and Chiu, W. J Struct Biol, 136: 214-225.




  • All publications from 2001 to 2016


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